The Health Secretary refused to rule out making it compulsory to take a coronavirus vaccine if one becomes available.

Matt Hancock’s comments came as US firm Moderna said its jab may be 94.5 per cent effective against the illness.

Downing Street insisted there were no plans to make vaccination mandatory but the Prime Minister’s official spokesman also declined to rule out compulsion.

Mr Hancock told talkRadio: “I hope that a very large proportion of people will want to take the vaccine because it’s the right thing to do.”

But he added: “We are not proposing at this stage to make it mandatory.”

Asked if he would rule that out, the Health Secretary said: “I have learned not to rule things out during this pandemic because you have to watch what happens and you have to make judgments accordingly.”

He said there were “complications” around making it mandatory because some people may not be able to take it for medical reasons.

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Downing Street also refused to rule out the prospect of making it a requirement for eligible people to take the vaccine although officials stressed that was not the plan.

“We want as many people as possible to take the vaccine,” the Prime Minister’s official spokesman said.

“It will go through rigorous safety checks before it is cleared for use.

“But we are not proposing to make it mandatory.”

Asked whether there could be restrictions – such as a public transport ban – imposed on people who refused a vaccine, the spokesman said: “We are not proposing to make it mandatory.”